RAF Typhoon FGR4s have joined forces with French aircraft in a combined operation on an hidden munitions depot in Syria employed by the IS group, according to the UK's MoD.
The location, located using surveillance, was thought to be storing arms and explosives, the statement said, and was situated in mountains just to the north of Palmyra in the heart of Syria.
"Our aircraft used Paveway IV guided bombs to target a series of entry passages leading to the site... early reports suggest the target was engaged successfully," the MoD said.
There was no indication of any harm to civilians in the attack late on Saturday and every plane involved returned safely, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as the so-called Islamic State - established militant control over parts of Syria and Iraq until 2019.
"This operation underscores British leadership, and commitment to work closely with allied nations, to eliminate any resurgence of Daesh and their violent and radical beliefs in the region," the British Defence Secretary the minister said.
RAF aircraft have carried out overwatch operations over Syria to "prevent any attempted comeback" of Islamic State after its defeat at the battle of Baghuz in 2019, the MoD reported.
"I must thank every member of the UK armed forces who took part in this mission for their expertise and their valour," the Defence Secretary said. "Including them were thousands of UK service members stationed over the holidays. This operation, to take out terrorist threats who endanger our security, demonstrates how British military are ready to step up, continuously, protecting the UK domestically and strong abroad."
During December, the US military executed what it called a "major assault" on Islamic State objectives in Syria, subsequent to an attack resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The UN reports Islamic State still boasts between 5,000 and 7,000 combatants in Iraq and Syria.
